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What is Neuroblastoma? Mainly affecting children, neuroblastoma is a relatively rare cancer of the sympathetic nervous system — a nerve network that carries messages from the brain throughout the body.
What is 3F8? 3F8 is a mouse derived monoclonal antibody developed by Dr. Cheung at Case Western Reserve University in the 1980’s, and later tested extensively at Memorial Sloan Kettering Cancer Center.
Morphoproteomics The change or alteration in the generation of proteins expressed by genes within an organism.
Clinical Trials Phase III Randomized Study of Induction Chemotherapy With or Without Filgrastim (G-CSF) Followed By Surgery, Myeloablative Therapy, and Radiotherapy With Isotretinoin With or Without Monoclonal Antibody Ch14.18 in Patients With High-Risk Neuroblastoma
Neuroblastoma Trial Briefing Following recent press reports and press releases regarding the new UK clinical trial of antibodies for the treatment of high risk neuroblastoma, this briefing briefly summarizes the problems regarding this trial.
Nisitinone Response of Metastatic Recurrent Neuroblastoma to Nitisinone: A Modulator of Tyrosine Metabolism
Nitisinone blocks the tyrosine pathway and may be effective in treating neuroblastoma.
14:18 Researchers from the Children's Oncology Group (COG) have demonstrated that a new experimental immunotherapy treatment using the chimeric monoclonal antibody (ch14.18), that targets a specific carbohydrate/lipid molecule (ganglioside, GD2) which is present on the surface of neuroblastoma tumor cells and cytokines (IL-2 and GM-CSF) resulted in a 20 percent improvement in cure rates compared to the standard treatment used in the past.
Neuroblastoma: New Hope for Kids Neuroblastoma is a childhood cancer of the nervous system that is often very aggressive. Patients who don't respond to surgery, chemotherapy and bone marrow transplant often face a death sentence. For the first time in more than a decade, researchers have developed a new therapy that could give these kids a fighting chance.
